Subjektive Symptomverbesserungen wurden von einem relevanten Anteil der Cannabis-nutzenden Parkinson-Patient:innen berichtet, wobei inhalatives THC stärker auf motorische Symptome wirkte als orales CBD.
Zusammenfassung
n=1.348 Parkinson-Patienten (1.123 bundesweit + 225 lokal), 8,4% berichteten Cannabis-Nutzung. >40% der Cannabis-Nutzer berichteten Reduktion von Schmerz und Muskelkrämpfen; >20% Verbesserung von Rigor/Akinesie, Freezing, Tremor, Depression und Angst. Inhaliertes THC reduzierte Akinesie/Rigor häufiger als orales CBD (50,0% vs. 35,4%, p<0.05).
Outcome8,4% der Befragten berichteten PD-bezogenen Cannabiskonsum; Schmerzreduktion und Linderung von Muskelkrämpfen bei >40% der Nutzer:innen; Inhalation von THC häufiger mit Reduktion von Akinese und Steifigkeit assoziiert als orale CBD-Einnahme (50,0% vs. 35,4%; p<0,05); 65% der Nicht-Nutzer:innen zeigten Interesse an MC
Vertrauen in die Evidenz
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Zweite von vier GRADE-Stufen, die Effektschätzung ist begrenzt verlässlich.
<h4>Background</h4>Little is known about the patients' view on treatment with medical cannabis (MC) for Parkinson's disease (PD).<h4>Objective</h4>To assess the PD community's perception of MC and patients' experience with MC.<h4>Methods</h4>Applying a questionnaire-based survey, we evaluated general knowledge and interest in MC as well as the frequency, modalities, efficacy, and tolerability of application. Questionnaires were distributed nationwide via the membership journal of the German Parkinson Association and locally in our clinic to control for report bias.<h4>Results</h4>Overall, 1.348 questionnaires (1.123 nationwide, 225 local) were analysed. 51% of participants were aware of the legality of MC application, 28% of various routes of administration (ROA) and 9% of the difference between delta9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). PD-related cannabis use was reported by 8.4% of patients and associated with younger age, living in large cities and better knowledge about the legal and clinical aspects of MC. Reduction of pain and muscle cramps was reported by more than 40% of cannabis users. Stiffness/akinesia, freezing, tremor, depression, anxiety and restless legs syndrome subjectively improved for more than 20% and overall tolerability was good. Improvement of symptoms was reported by 54% of users applying oral CBD and 68% inhaling THC-containing cannabis. Compared to CBD intake, inhalation of THC was more frequently reported to reduce akinesia and stiffness (50.0% vs. 35.4%; p < 0.05). Interest in using MC was reported by 65% of non-users.<h4>Conclusion</h4>MC is considered as a therapeutic option by many PD patients. Nevertheless, efficacy and different ROA should further be investigated.