Cannabiskonsum war nach Adjustierung für Kindheitstrauma nicht mehr signifikant mit Psychose assoziiert; sexueller Kindheitsmissbrauch erwies sich als deutlich stärkerer Prädiktor.
Zusammenfassung
Bevölkerungssurvey (n=7.403, Adult Psychiatric Morbidity Survey 2007); Cannabiskonsum allein nach Adjustierung für Kindheitstrauma nicht signifikant für Psychosediagnose; Kindheitliche sexuelle Traumatisierung: OR 6,10 für Psychose; kombiniert Trauma + Cannabiskonsum: OR 7,84 — Cannabis-Psychose-Assoziation durch Kindheitstrauma moderiert.
P
PopulationErwachsene aus der britischen Allgemeinbevölkerung (Adult Psychiatric Morbidity Survey 2007), n=7403
I
InterventionCannabiskonsum (selbstberichtet)
C
KontrolleKein Cannabiskonsum
O
OutcomeIm bivariaten Modell war Cannabiskonsum prädiktiv für Psychose-Diagnose; im multivariaten Modell unter Berücksichtigung von sexuellem Kindheitstrauma war der Effekt attenuiert und nicht mehr statistisch signifikant (OR nicht berichtet). Nicht-konsensueller Sex in der Kindheit war unabhängig assoziiert (OR 6,10); Interaktion Kindheitstrauma x Cannabis: OR 7,84 (Vorsicht: übergeordneter Analyseschritt nicht signifikant).
Vertrauen in die Evidenz
Sehr niedrigNiedrigModeratHoch
Niedrig
Zweite von vier GRADE-Stufen, die Effektschätzung ist begrenzt verlässlich.
<h4>Background</h4>Cannabis consumption continues to be identified as a causal agent in the onset and development of psychosis. However, recent findings have shown that the effect of cannabis on psychosis may be moderated by childhood traumatic experiences.<h4>Method</h4>Using hierarchical multivariate logistic analyses the current study examined both the independent effect of cannabis consumption on psychosis diagnosis and the combined effect of cannabis consumption and childhood sexual abuse on psychosis diagnosis using data from the Adult Psychiatric Morbidity Survey 2007 (n=7403).<h4>Results</h4>Findings suggested that cannabis consumption was predictive of psychosis diagnosis in a bivariate model; however, when estimated within a multivariate model that included childhood sexual abuse, the effect of cannabis use was attenuated and was not statistically significant. The multivariate analysis revealed that those who had experienced non-consensual sex in childhood were over six times [odds ratio (OR) 6.10] more likely to have had a diagnosis of psychosis compared with those who had not experienced this trauma. There was also a significant interaction. Individuals with a history of non-consensual sexual experience and cannabis consumption were over seven times more likely (OR 7.84) to have been diagnosed with psychosis compared with those without these experiences; however, this finding must be interpreted with caution as it emerged within an overall analytical step which was non-significant.<h4>Conclusions</h4>Future studies examining the effect of cannabis consumption on psychosis should adjust analyses for childhood trauma. Childhood trauma may advance existing gene-environment conceptualisations of the cannabis-psychosis link.