Association between Cannabis use and transitional cell carcinoma.
Chacko et al.·Urology
SchadenGRADENiedrig70 Zitate
Stichproben = 156 Pat.
KontrolleAltersgematchte Kontrollen ohne…
EndpunktMarihuanakonsum
Verblindungn.a.
DesignFall-Kontroll-Studie
Applikationinhalativ
”Kernaussage
Habitueller Cannabiskonsum war signifikant mit dem Auftreten sowie mit Stadium, Grad und Rezidivhäufigkeit des Urothelkarzinoms assoziiert.
Zusammenfassung
n=52 Männer <60 Jahre mit Transitionalzellkarzinom (TCC) vs. n=104 altersgematchte Kontrollen. 88,5% der TCC-Patienten berichteten gewohnheitsmäßigen Cannabiskonsum vs. 69,2% der Kontrollen (P=0.008). Cannabiskonsum korrelierte innerhalb der TCC-Gruppe signifikant mit Tumorstadium, -grad und Rezidivhäufigkeit. Hinweis auf erhöhtes TCC-Risiko durch Cannabis-Rauchen.
P
PopulationMänner unter 60 Jahren mit Urothelkarzinom (Transitionalzellkarzinom), n=52 Fälle, n=104 altersgematchte Kontrollen ohne Karzinom-/Hämaturie-Anamnese
KontrolleAltersgematchte Kontrollen ohne Transitionalzellkarzinom
O
OutcomeSignifikant höhere Rate an habituellem Cannabiskonsum bei Fällen vs. Kontrollen (88,5% vs. 69,2%; p=0,008); Cannabiskonsum korrelierte signifikant mit Tumorstadium, -grad und Rezidivanzahl
Vertrauen in die Evidenz
Sehr niedrigNiedrigModeratHoch
Niedrig
Zweite von vier GRADE-Stufen, die Effektschätzung ist begrenzt verlässlich.
<h4>Objectives</h4>Cannabis smoking has been implicated as a causative factor in traditionally tobacco-related tumors of the head and neck and of the lung. When associated with Cannabis use, such tumors occur in a much younger patient population than do similar tumors in tobacco smokers. Owing to the large number of young men with a history of Cannabis presenting with transitional cell carcinoma to VA facilities, this study was designed to compare the Cannabis use among young (aged less than 60 years) transitional cell carcinoma patients with that among age-matched controls.<h4>Methods</h4>Fifty-two men aged less than 60 years presenting consecutively with transitional cell carcinoma and 104 age-matched controls (defined by having no history of transitional cell carcinoma, hematuria, or irritative voiding symptoms, as well as unremarkable results on urinalysis and urine cytology) completed questionnaires about exposure to various potential carcinogens, including radiation, Agent Orange, smoked or processed meats, dyes, tobacco, and Cannabis.<h4>Results</h4>Of the 52 transitional cell carcinoma patients, 46 (88.5%) reported a history of habitual Cannabis usage, and 72 (69.2%) of the age-matched controls gave a history of habitual Cannabis use. This difference was statistically significant (P = 0.008). In those with transitional cell carcinoma, Cannabis use significantly correlated with tumor stage, grade, and number of recurrences.<h4>Conclusions</h4>Cannabis smoking might increase the risk of transitional cell carcinoma.