Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysis.
Han et al.·Psychiatry researchImpact 4.1
Klarer NutzenGRADEHoch43 Zitate
Stichprobek = 8 Studien n = 316 Pat.
Dauerunklar
KontrollePlacebo
EndpunktAngstintensität
Verblindungunklar
DesignMeta-Analyse
Cannabinoidcbd
”Kernaussage
CBD zeigte einen signifikanten Effekt auf Angststörungen mit großer Effektgröße (Hedges' g = -0,92, 95% KI -1,80 bis -0,04).
Zusammenfassung
Systematische Review + Meta-Analyse zu CBD bei Angststörungen (GAD, SAD, PTSD); k=8 RCTs, n=316 Teilnehmende. Signifikanter Effekt von CBD auf Angst mit großer Effektstärke (Hedges' g=-0.92, 95% CI -1.80 bis -0.04, p<0.05). Einschränkung: begrenzte klinische Stichprobengröße.
P
PopulationErwachsene mit Angststörungen (GAD, SAD, PTSD), gepoolt n=316
I
InterventionCannabidiol (CBD), verschiedene Dosierungen und Applikationsformen
C
KontrollePlacebo
O
OutcomeSignifikante Angstreduktion durch CBD (Hedges' g = -0,92, 95% CI -1,80 bis -0,04)
Vertrauen in die Evidenz
Sehr niedrigNiedrigModeratHoch
Hoch
Höchste von vier GRADE-Stufen, die Effektschätzung ist sehr verlässlich.
Cannabidiol (CBD), as one of the phytocannabinoids, has a wide range of therapeutic properties for various neuropsychiatric disorders due to central nervous system effects. These therapeutic properties demonstrated by preclinical and clinical studies encompass more than just anticonvulsant, anti-arthritic, analgesic, anti-inflammatory, antioxidant, antitumor, antiemetic, antipsychotic and neuroprotective effects. It has been hypothesized that CBD holds potential in the treatment of various neuropsychiatric and anxiety disorders. Thus, PRISMA was used as a guide for our systematic review. Eight of the 1550 articles screened in June 2023 were eligible for meta-analysis. Based on the 316 participants included in these eight articles, this meta-analysis revealed a substantial significant impact of CBD on anxiety with a considerable effect size (Hedges' g = -0.92, 95% CI -1.80 to -0.04). In addition, this meta-analysis focuses on the efficacy of CBD in treating anxiety disorders such as generalized anxiety disorder (GAD), social anxiety disorder (SAD), and post-traumatic stress disorder (PTSD). However, caution should be exercised in interpreting our findings due to the limited size of the clinical sample, and additional trials ought to be carried out if deemed necessary.