Studienlage · Detail
The role of the endocannabinoid system in aetiopathogenesis of endometriosis: A potential therapeutic target
Unklar
29 Zitate
StichprobeNarrative Review
Verblindungn.a.
DesignNarrative Review
Kernaussage
Narrative Review ohne primäre Interventionsergebnisse; ECS zeigt potenzielle Rolle in Endometriose-Pathogenese, aber Evidenz ist begrenzt und teilweise widersprüchlich.
Zusammenfassung
Narrative Review zur Rolle des Endocannabinoid-Systems in der Ätiopathogenese der Endometriose; diskutiert CB1/CB2-Rezeptoren, Anandamid und 2-AG im endometrialen Gewebe sowie potenzielle therapeutische Implikationen von Cannabinoiden bei Endometriose-assoziiertem Schmerz.
ZusammenfassungNarratives Review zur Rolle des Endocannabinoid-Systems (ECS) in der Ätiopathogenese der Endometriose. Zusammenfassung der Literatur zeigt Dysregulation von CB1 (Downregulation) und TRPV1 (Upregulation) bei Endometriose sowie Beteiligung des ECS an Zellmigration, Proliferation, Apoptose und Inflammation. Inkonsistente Studienlage mit limitierten Stichprobengrößen — zukünftige Forschung mit größeren Kohorten und standardisierten Kontrollen erforderlich.
Qualitätsprofil
Größe
—
Verblindung
—
Effektstärke
—
Zitate / Jahr
★★★★★
Autoren
Teilen
Abstract
Endometriosis affects a large proportion of women during their reproductive years and is associated with pain and infertility, also affecting psychological wellbeing and quality of life. The pathogenesis of the disease remains unclear, although it is believed to be multifactorial. The endocannabinoid system (ECS) consists of a number of ligands, receptors and enzymes, and has gained interests in endometriosis research. This review aims to summarise all available evidence reporting the roles of the ECS in endometriosis. A literature search of the PubMed, EMBASE, and Web of Science electronic medical databases was performed. Original and review articles published in peer-reviewed journals were included. No publication date or publication status restrictions were imposed. Significant differences in the concentrations and expressions of the components of the ECS were reported in the eutopic and ectopic endometrium, and the systemic circulation of women with endometriosis compared to controls. Endometriosis appears to be associated with downregulation of CB1 receptors and upregulation of TRPV1 receptors. The role of CB1 and progesterone in anti-inflammatory action and the role of TRPV1 in inflammation and pain are of particular interests. Furthermore, the ECS has been reported to be involved in processes relevant to endometriosis, including cell migration, cell proliferation, apoptosis, inflammation, and interacts with sex steroid hormones. The ECS may play a role in disease establishment, progression, and pain in endometriosis. However, reports are based on studies of limited size and there are inconsistencies among the definition of their control groups. There are also conflicting reports regarding precise involvement of the ECS in endometriosis. Future research with larger numbers, strict inclusion and exclusion criteria and detailed clinical information is imperative.
„Was dem Handeln im Weg steht, wird zum Weg.“