Häufiger Cannabiskonsum ist mit einem etwa 2-fach erhöhten TGCT-Risiko assoziiert, bei Nichtseminomen bis zu 3-fach erhöht.
Zusammenfassung
Hospital-basierte Fall-Kontroll-Studie (n=187 Hodentumor-Fälle, n=148 Kontrollen); häufige Cannabisnutzung (täglich oder mehr) vs. Nicht-Nutzer OR=2,2 (95%-CI 1,0–5,1) für Keimzelltumoren gesamt; für Nicht-Seminom: häufige Nutzung OR=3,1 (95%-CI 1,2–8,2); Langzeitnutzung (≥10 Jahre) OR=2,4 (95%-CI 1,0–6,1).
P
PopulationMänner mit testikulären Keimzelltumoren (TGCT), n=187 Fälle und n=148 männliche Kontrollpersonen, Alter 18–50 Jahre, aus Texas, Louisiana, Arkansas oder Oklahoma
I
InterventionCannabiskonsum (häufig: täglich oder häufiger; Langzeitkonsum: ≥10 Jahre)
C
KontrolleMännliche Freund-Kontrollen ohne TGCT-Diagnose
O
OutcomeHäufiger Cannabiskonsum assoziiert mit erhöhtem TGCT-Risiko (OR 2,2; 95%-KI 1,0–5,1); bei Nichtseminomen: häufiger Konsum OR 3,1 (95%-KI 1,2–8,2), Langzeitkonsum OR 2,4 (95%-KI 1,0–6,1)
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Autoren
Trabert B, Sigurdson AJ, Sweeney AM, Strom SS, McGlynn KA.
<h4>Background</h4>Since the early 1970s, the incidence of testicular germ cell tumors (TGCTs) in the United States has been increasing; however, potential environmental exposures accounting for this increase have not been identified. A previous study reported a significant association between frequent and long-term current Cannabis users and TGCT risk. The purpose of this study was to evaluate the relation between Cannabis use and TGCTs in a hospital-based case-control study.<h4>Methods</h4>TGCT patients diagnosed between January 1990 and October 1996 (n = 187) and male friend controls (n = 148) were enrolled in the study. All participants were between the ages of 18 and 50 at the time of diagnosis and resided in Texas, Louisiana, Arkansas, or Oklahoma. Associations of Cannabis use and TGCTs were estimated using unconditional logistic regression, adjusting for age, race, prior cryptorchidism, cigarette smoking, and alcohol intake.<h4>Results</h4>Overall, patients with TGCTs were more likely to be frequent Cannabis users (daily or greater) compared with controls (odds ratio [OR], 2.2; 95% confidence interval [CI], 1.0-5.1). Histological-specific analyses revealed that patients with nonseminoma were significantly more likely than controls to be frequent users (OR, 3.1; 95% CI, 1.2-8.2) and long-term (≥ 10 years) users (OR, 2.4; 95% CI, 1.0-6.1).<h4>Conclusions</h4>The finding of an association between frequent Cannabis use and TGCTs, particularly among men with nonseminoma, was consistent with the findings of a previous report. Additional studies of Cannabis use and TGCTs are warranted, especially studies evaluating the role of endocannabinoid signaling and cannabinoid receptors in TGCTs.